Thymosin Beta 4 is a synthetic version of the naturally occurring peptide present in virtually all-human and animal cells, Thymosin Beta 4 (Tß4). Tβ4 is not a growth factor; rather, it is a major actin regulating peptide. Tβ4 has been found to play an important role in protection, regeneration, and re-modeling of injured or damaged tissues. The gene for Tβ4 has also been found to be one of the first to be up-regulated after a wound occurs.
One of Tß4 key mechanisms of action is its ability to regulate the cell-building protein, Actin, a vital component of cell structure and movement. Of the thousands of proteins present in cells, actin represents up to 10% of the total proteins that therefore plays a major role in the genetic makeup of the cell.
This potent peptide is a member of a ubiquitous family of 16 related molecules with a high conservation of sequence and localization in most tissues and circulating cells in the body. Tß4 not only binds to actin, but also blocks actin polymerization and is the actin-sequestering molecule in eukaryotic cells.
Tß4 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells.
An additional key factor of Tß4 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
Research confirms that Tß4 is a potent, naturally occurring wound repair factor with anti-inflammatory properties. Tß4 is different from other repair factors, such as growth factors, in that it promotes endothelial and keratinocyte migration. It also does not bind to the extracellular matrix and has a very low molecular weight meaning it can travel relatively long distances through tissues.
*Note: If you are a registered professional athlete please consult the ASADA or WADA guidelines and your coach, club and/or sporting body before using this peptide.